For Building Muscle: Creatine Monohydrate or Whey Protein?

Evidence-based comparison for building muscle

Creatine Monohydrate

Creatine increases intramuscular phosphocreatine → more ATP for high-intensity sets → 5-15% strength gain. Does NOT directly build muscle — it enables harder training.

Whey Protein

Whey provides leucine (mTOR trigger) + amino acids for muscle protein synthesis. 25-35% increase in MPS post-ingestion. Directly builds muscle tissue.

Verdict

Both — not either/or. Creatine for performance + whey for tissue repair. Take creatine daily (5g, timing irrelevant), whey post-workout (20-40g). Synergistic when combined.

Best choice: both